Estimation of Glomerular Filtration Rate by Sinistrin Clearance Using Various Approaches

Transcutaneous measurement of glomerular filtration rate using FITC-sinistrin in rats.

BACKGROUND Inulin/sinistrin (I/S) clearance is a gold standard for an accurate assessment of glomerular filtration rate (GFR). Here we describe and validate an approach for a transcutaneous determination of GFR by using fluorescein-isothiocyanate-labelled sinistrin (FITC-S) in rats. METHODS Using a small animal imager, fluorescence is measured over the depilated ear of a rat after the injecti...

A practical approach to glomerular filtration rate measurements: creatinine clearance estimation using cimetidine.

Determination of creatinine clearance (Ccr) is not a reliable indicator of glomerular filtration rate (GFR), owing to tubular secretion of creatinine. It has been reported that Ccr measurements can approximate true GFR after cimetidine (Ci) administration. In this study, GFR was estimated by Cockcroft and Gault's equation (C(C-G)) based on measurement of plasma creatinine, and Ccr was determine...

Using Mathematical Algorithms to Modify Glomerular Filtration Rate Estimation Equations

BACKGROUND The equations provide a rapid and low-cost method of evaluating glomerular filtration rate (GFR). Previous studies indicated that the Modification of Diet in Renal Disease (MDRD), Chronic Kidney Disease-Epidemiology (CKD-EPI) and MacIsaac equations need further modification for application in Chinese population. Thus, this study was designed to modify the three equations, and compare...

Glomerular Filtration Rate (GFR) determination via individual kinetics of the polyfructosan sinistrin vs

Improved Glomerular Filtration Rate Estimation by an Artificial Neural Network

BACKGROUND Accurate evaluation of glomerular filtration rates (GFRs) is of critical importance in clinical practice. A previous study showed that models based on artificial neural networks (ANNs) could achieve a better performance than traditional equations. However, large-sample cross-sectional surveys have not resolved questions about ANN performance. METHODS A total of 1,180 patients that ...